Butylated hydroxyanisole stimulates heme oxygenase-1 gene expression and inhibits neointima formation in rat arteries
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چکیده
منابع مشابه
Single perivascular delivery of mitomycin C stimulates p21 expression and inhibits neointima formation in rat arteries.
OBJECTIVE Mitomycin C (MMc) is an antibiotic that exerts a potent antiproliferative effect in tumor cells. Because the proliferation of vascular smooth muscle cells (VSMCs) plays a prominent role in the development of restenosis after percutaneous coronary interventions, the present study examined the effect of MMc on VSMC proliferation and on neointima formation after arterial balloon injury. ...
متن کاملAdenovirus-mediated heme oxygenase-1 gene delivery inhibits injury-induced vascular neointima formation.
BACKGROUND Recent studies have demonstrated that systemic pharmacological induction of heme oxygenase-1 (HO-1), the inducible isoform of the initial and rate-limiting enzyme for heme catabolism, attenuates neointima formation after experimental vascular injury. We have now investigated the ability of localized adenovirus-mediated HO-1 (Ad-HO-1) gene delivery to modify arterial remodeling after ...
متن کاملAdenovirus-mediated heme oxygenase-1 gene expression stimulates apoptosis in vascular smooth muscle cells.
BACKGROUND Heme oxygenase-1 (HO-1) catalyzes the degradation of heme into biliverdin, iron, and carbon monoxide (CO). Although HO-1 is induced in vascular smooth muscle cells (SMCs), the biological role of HO-1 in these cells has not been completely characterized. METHODS AND RESULTS In the present study, we overexpressed HO-1 in rat aortic SMCs by generating a recombinant defective adenoviru...
متن کاملActivation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival.
The present study determined whether AMP-activated protein kinase (AMPK) regulates heme oxygenase (HO)-1 gene expression in endothelial cells (ECs) and if HO-1 contributes to the biological actions of this kinase. Treatment of human ECs with the AMPK activator 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) stimulated a concentration- and time-dependent increase in HO-1 protein and ...
متن کاملInduction of heme oxygenase-1 expression inhibits platelet-dependent thrombosis.
Heme oxygenase-1 (HO-1) plays a key role in protecting tissue from oxidative stress. Although some studies implicate HO-1 in modulating thrombosis after vascular injury, the impact of HO-1 on the rate of clot formation in vivo is poorly defined. This study examined the potential function of HO-1 in regulating platelet-dependent arterial thrombosis. Platelet-rich thrombi were induced in C57BL/6J...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2007
ISSN: 0008-6363
DOI: 10.1016/j.cardiores.2007.01.017